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编 号：F234724
分子式：C16H14N2O3
分子量：282.29
分子式：C16H14N2O3
分子量：282.29
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CAS No: 187585-11-1
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生物活性：
DD1, a proteasome inhibitor, targets Bax activation and P70S6K degradation during acute myeloid leukemia (AML) apoptosis. DD1 induces apoptosis in the caspase-dependent manner.?DD1 induces mitochondrial membrane depolarization and Bad dephosphorylation.
体外研究：
DD1 (20 μM; 96 h) shows antiproliferation activity in a dose- and time-dependent manner in U937 cells.DD1 induces cell cycle arrest at G2/M phase and apoptosis.DD1 (10, 20 μM; 48 h) induces mitochondrial membrane depolarization, Bax upregulation and Bad dephosphorylation.DD1 (2-20 μM; 40 h) shows inhibitor for chymotrypsin-like activity in U937 lysates.
DD1, a proteasome inhibitor, targets Bax activation and P70S6K degradation during acute myeloid leukemia (AML) apoptosis. DD1 induces apoptosis in the caspase-dependent manner.?DD1 induces mitochondrial membrane depolarization and Bad dephosphorylation.
体外研究：
DD1 (20 μM; 96 h) shows antiproliferation activity in a dose- and time-dependent manner in U937 cells.DD1 induces cell cycle arrest at G2/M phase and apoptosis.DD1 (10, 20 μM; 48 h) induces mitochondrial membrane depolarization, Bax upregulation and Bad dephosphorylation.DD1 (2-20 μM; 40 h) shows inhibitor for chymotrypsin-like activity in U937 lysates.
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