产品
编 号：F234680
分子式：C25H26N6O
分子量：426.51
分子式：C25H26N6O
分子量：426.51
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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结构图
CAS No: 1875036-74-0
产品详情
生物活性：
BI8622 is a specific inhibitor of the ubiquitin ligase HUWE1 with an IC50 of 3.1 μM.
体外研究：
BI8622 induces HUWE1 ectopically expresses to abolish ubiquitination of MCL1 with an IC50 value of 6.8 μM in HeLa cells.BI8622 suppresses colony formation of Ls174T cells with estimated IC50 value of 8.4 μM.BI8622 (10 μM; 1-4 days) treatment retards passage of Ls174T cells through all phases of the cell cycle, with the effect being strongest for G1.BI8622 (0-50 μM; 16 hours) retards the degradation of MCL1 in response to UV irradiation by inhibiting HUWE1 in HeLa cells.BI8622 inhibits MYC-dependent transactivation in colorectal cancer cells.
BI8622 is a specific inhibitor of the ubiquitin ligase HUWE1 with an IC50 of 3.1 μM.
体外研究：
BI8622 induces HUWE1 ectopically expresses to abolish ubiquitination of MCL1 with an IC50 value of 6.8 μM in HeLa cells.BI8622 suppresses colony formation of Ls174T cells with estimated IC50 value of 8.4 μM.BI8622 (10 μM; 1-4 days) treatment retards passage of Ls174T cells through all phases of the cell cycle, with the effect being strongest for G1.BI8622 (0-50 μM; 16 hours) retards the degradation of MCL1 in response to UV irradiation by inhibiting HUWE1 in HeLa cells.BI8622 inhibits MYC-dependent transactivation in colorectal cancer cells.
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