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编 号：F234489
分子式：C46H52Na2O16
分子量：906.88
分子式：C46H52Na2O16
分子量：906.88
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CAS No: 187269-60-9
产品详情
生物活性：
Bimosiamose disodium (TBC-1269Z) is a nonoligosaccharide pan-selectin inhibitor with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively. Bimosiamose disodium has anti-inflammatory effects.
体内研究：
Bimosiamose (TBC-1269; 25 mg/kg; intravenous injection; Sprague-Dawley rats) treatment shows a significant increase in survival. Best overall survival, 70%, is observed when TBC-1269 is administered 15 minutes before reperfusion, and also shows a marked decrease in liver enzyme levels at 6 hours after reperfusion. Neutrophil migration is also significantly ameliorated (81%). The histologic damage scores is also improved.Animal Model:Sprague-Dawley rats (200-225g) with ischemia and reperfusion (I/R)
Dosage:25 mg/kg
Administration:Intravenous injection
Result:Showed a significant increase in survival compared with controls.
体外研究：
Bimosiamose (TBC-1269) operates by inhibiting neutrophil recruitment to the site of inflammation through blocking the initial rolling phase of recruitment. Bimosiamose (TBC-1269)inhibits cell recruitment and does not possess any cytotoxic effect on neutrophils.
Bimosiamose disodium (TBC-1269Z) is a nonoligosaccharide pan-selectin inhibitor with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively. Bimosiamose disodium has anti-inflammatory effects.
体内研究：
Bimosiamose (TBC-1269; 25 mg/kg; intravenous injection; Sprague-Dawley rats) treatment shows a significant increase in survival. Best overall survival, 70%, is observed when TBC-1269 is administered 15 minutes before reperfusion, and also shows a marked decrease in liver enzyme levels at 6 hours after reperfusion. Neutrophil migration is also significantly ameliorated (81%). The histologic damage scores is also improved.Animal Model:Sprague-Dawley rats (200-225g) with ischemia and reperfusion (I/R)
Dosage:25 mg/kg
Administration:Intravenous injection
Result:Showed a significant increase in survival compared with controls.
体外研究：
Bimosiamose (TBC-1269) operates by inhibiting neutrophil recruitment to the site of inflammation through blocking the initial rolling phase of recruitment. Bimosiamose (TBC-1269)inhibits cell recruitment and does not possess any cytotoxic effect on neutrophils.
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