产品
编 号：F234322
分子式：C8H4Cl2N2O2
分子量：231.04
分子式：C8H4Cl2N2O2
分子量：231.04
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
410
In-stock
10mg
544
In-stock
50mg
1898
In-stock
结构图
CAS No: 18711-16-5
产品详情
生物活性：
NS309 is a potent and selective activator of the Ca2+-activated SK/IK potassium channels, but displays no activity at BK channels.
体内研究：
NS309 (2 mg/kg; i.p.) protects against SCI/R in rabbits.Animal Model:Adult New Zealand white rabbits (2.5-3.0 kg)
Dosage:2 mg/kg
Administration:Intraperitoneal injection
Result:Significantly improved neurological outcome of SCI/R challenged rabbits.
体外研究：
NS309 (40?nM) activates both hSK3 and hIK channels, with the largest effect on hIK channels (8.5-fold increase in current compares to 1.9-fold increase in current for hSK3 channels).NS309 (10 μM) significantly increases the whole cell SK currents and hyperpolarized detrusor smooth muscle (DSM) cells resting membrane potential.NS309 inhibits the spontaneous phasic contraction amplitude, force, frequency, duration and tone of isolated DSM strips in a concentration-dependent manner.
NS309 is a potent and selective activator of the Ca2+-activated SK/IK potassium channels, but displays no activity at BK channels.
体内研究：
NS309 (2 mg/kg; i.p.) protects against SCI/R in rabbits.Animal Model:Adult New Zealand white rabbits (2.5-3.0 kg)
Dosage:2 mg/kg
Administration:Intraperitoneal injection
Result:Significantly improved neurological outcome of SCI/R challenged rabbits.
体外研究：
NS309 (40?nM) activates both hSK3 and hIK channels, with the largest effect on hIK channels (8.5-fold increase in current compares to 1.9-fold increase in current for hSK3 channels).NS309 (10 μM) significantly increases the whole cell SK currents and hyperpolarized detrusor smooth muscle (DSM) cells resting membrane potential.NS309 inhibits the spontaneous phasic contraction amplitude, force, frequency, duration and tone of isolated DSM strips in a concentration-dependent manner.
产品资料
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