产品
编 号：F234159
分子式：C20H20N4O3
分子量：364.4
分子式：C20H20N4O3
分子量：364.4
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
50mg
询价
询价
结构图
CAS No: 186953-56-0
产品详情
生物活性：
Pafuramidine (DB289) is an orally active proagent of Furamidine (HY-110137A). Pafuramidine is a potent anti-parasitic agent, can be used to research trypanosomiasis, Pneumocystis pneumonia and malaria.
体内研究：
Pafuramidine (1-10 mg/kg; p.o.; for 5 or 10 days) cures some trypanosomes-infected monkeys.Pafuramidine (2.5-100 mg/kg; p.o.; for 4 or 5 days) cures some Trypanosoma brucei-infected mice.Animal Model:Vervet monkeys (infected by intravenous injection of 104 trypanosomes)
Dosage:1, 3, and 10 mg/kg (group 1/2/3); 10 mg/kg (group 4/5)
Administration:p.o.; 5 consecutive days for group 1/2/3 (started on the 7th day postinfection); 10 days for group 4 (started on the 14th day postinfection); 10 days for group 5 (started on the 28th day postinfection). Post-treatment monitoring was maintained for a period of 180 days.
Result:Cured all three monkeys in group 3 at 10 mg/kg, and did not recur during the monitoring period.All three monkeys in group 4 became aparasitemic by day 5 of dosing, but only two of three monkeys remained free of blood parasites until 180 days post-treatment monitoring.All three monkeys in group 5 became aparasitemic by day 4 of dosing, but only two of three of monkeys remained free of blood trypanosomes by the end of the 180 days of post-treatment monitoring.
Animal Model:Female NMRI mice (infected intraperitoneally with 2 × 104 STIB900 bloodstream forms)
Dosage:2.5, 5, 25 and 50 mg/kg
Administration:p.o.; for 4 days (started on the 4th day postinfection)
Result:Cured all four mice at 25 and 50 mg/kg.
Animal Model:Female NMRI mice (infected intraperitoneally with 2 × 104 GVR35 bloodstream forms)
Dosage:25, 50 and 100 mg/kg
Administration:p.o.; for 5 days (started on the 21st day postinfection)
Result:Showed good CNS activity in the GVR35 CNS model, with 3/5 mice cured at 100 mg/kg.
Pafuramidine (DB289) is an orally active proagent of Furamidine (HY-110137A). Pafuramidine is a potent anti-parasitic agent, can be used to research trypanosomiasis, Pneumocystis pneumonia and malaria.
体内研究：
Pafuramidine (1-10 mg/kg; p.o.; for 5 or 10 days) cures some trypanosomes-infected monkeys.Pafuramidine (2.5-100 mg/kg; p.o.; for 4 or 5 days) cures some Trypanosoma brucei-infected mice.Animal Model:Vervet monkeys (infected by intravenous injection of 104 trypanosomes)
Dosage:1, 3, and 10 mg/kg (group 1/2/3); 10 mg/kg (group 4/5)
Administration:p.o.; 5 consecutive days for group 1/2/3 (started on the 7th day postinfection); 10 days for group 4 (started on the 14th day postinfection); 10 days for group 5 (started on the 28th day postinfection). Post-treatment monitoring was maintained for a period of 180 days.
Result:Cured all three monkeys in group 3 at 10 mg/kg, and did not recur during the monitoring period.All three monkeys in group 4 became aparasitemic by day 5 of dosing, but only two of three monkeys remained free of blood parasites until 180 days post-treatment monitoring.All three monkeys in group 5 became aparasitemic by day 4 of dosing, but only two of three of monkeys remained free of blood trypanosomes by the end of the 180 days of post-treatment monitoring.
Animal Model:Female NMRI mice (infected intraperitoneally with 2 × 104 STIB900 bloodstream forms)
Dosage:2.5, 5, 25 and 50 mg/kg
Administration:p.o.; for 4 days (started on the 4th day postinfection)
Result:Cured all four mice at 25 and 50 mg/kg.
Animal Model:Female NMRI mice (infected intraperitoneally with 2 × 104 GVR35 bloodstream forms)
Dosage:25, 50 and 100 mg/kg
Administration:p.o.; for 5 days (started on the 21st day postinfection)
Result:Showed good CNS activity in the GVR35 CNS model, with 3/5 mice cured at 100 mg/kg.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备