产品
编 号：F234052
分子式：C15H22Cl2N2O3
分子量：349.25
分子式：C15H22Cl2N2O3
分子量：349.25
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CAS No: 186826-17-5
产品详情
生物活性：
ML 10302 hydrochloride is a potent and selective 5-HT4 receptor agonist, with an EC50 of 4 nM. ML 10302 hydrochloride displays more than 680-fold selectivity over 5-HT3 receptor in binding assay.
体内研究：
ML 10302 hydrochloride (20?mg/kg; s.c.) induces the soluble form of amyloid precursor protein (sAPPα) production in the cortex of mice.Animal Model:8-weeks old adult male C57BL/6j wild-type mice (23-27?g)
Dosage:5 mg/kg, 10 mg/kg, 20?mg/kg
Administration:Subcutaneous injection
Result:Significantly increased sAPPα level in the cortex.
体外研究：
ML 10302 hydrochloride shows Kis of 1.07 nM and 782 nM for 5-HT4 receptor and 5-HT3 receptor, respectively, in binding assay.
ML 10302 hydrochloride is a potent and selective 5-HT4 receptor agonist, with an EC50 of 4 nM. ML 10302 hydrochloride displays more than 680-fold selectivity over 5-HT3 receptor in binding assay.
体内研究：
ML 10302 hydrochloride (20?mg/kg; s.c.) induces the soluble form of amyloid precursor protein (sAPPα) production in the cortex of mice.Animal Model:8-weeks old adult male C57BL/6j wild-type mice (23-27?g)
Dosage:5 mg/kg, 10 mg/kg, 20?mg/kg
Administration:Subcutaneous injection
Result:Significantly increased sAPPα level in the cortex.
体外研究：
ML 10302 hydrochloride shows Kis of 1.07 nM and 782 nM for 5-HT4 receptor and 5-HT3 receptor, respectively, in binding assay.
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