产品
编 号:F232554
分子式:C25H28F4N2O6
分子量:528.49
产品类型
结构图
CAS No: 1863905-38-7
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产品详情
生物活性:
PF-06737007 is a potent pan-Trk inhibitor in cell-based assays with IC50s of 7.7 nM, 15 nM and 3.9 nM for TrkA, TrkB and TrkC, respectively. Anti-hyperalgesic effect.
体外研究:
PF-06737007 (Compound 13b) exhibits superb Trk selectivity with >95% inhibition of TrkA with no other kinase being inhibited by >40% at 1 μM.