产品
编 号：F232301
分子式：C20H17BCl2N4O6
分子量：491.09
分子式：C20H17BCl2N4O6
分子量：491.09
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 1862212-48-3
产品详情
生物活性：
TH1217 (ZINC1775962367) is a potent and selective dCTPase pyrophosphatase 1 (dCTPase) inhibitor, with an IC50 of 47 nM. TH1217 enhances the cytotoxic effect of cytidine analogues in leukemia cells. TH1217 also could modulate SARS-Cov-2 interactors, so it shows activity of against COVID-19.
体外研究：
TH1217 (compound 30) inhibits dCTPase and enhances aqueous solubility (>100 μM) and improves plasma stability in vitro(t4h=86%).TH1217 presents suitable mouse microsomal half-lives (109 minutes).TH1217 displays well cell permeability (8.66×10-6/1.30×10-3 cm/s) and CYP inhibition.
TH1217 (ZINC1775962367) is a potent and selective dCTPase pyrophosphatase 1 (dCTPase) inhibitor, with an IC50 of 47 nM. TH1217 enhances the cytotoxic effect of cytidine analogues in leukemia cells. TH1217 also could modulate SARS-Cov-2 interactors, so it shows activity of against COVID-19.
体外研究：
TH1217 (compound 30) inhibits dCTPase and enhances aqueous solubility (>100 μM) and improves plasma stability in vitro(t4h=86%).TH1217 presents suitable mouse microsomal half-lives (109 minutes).TH1217 displays well cell permeability (8.66×10-6/1.30×10-3 cm/s) and CYP inhibition.
产品资料
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