产品
编 号：F232107
分子式：C12H10FN3
分子量：215.23
分子式：C12H10FN3
分子量：215.23
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CAS No: 186033-14-7
产品详情
生物活性：
NS-8, a pyrrole derivative, activates the Ca2+-sensitive k+-channel. NS-8 can suppress the micturition reflex by decreasing afferent pelvic nerve activity. NS-8 can be used in the research of urinary frequency and incontinence.
体内研究：
NS-8 (intravenous injection or intraduodenal administration, 3 and 10 mg/kg) suppresses the rat micturition reflex by inhibiting afferent pelvic nerve activity in rats.Animal Model:Rats
Dosage:1, 3 and 10 mg/kg
Administration:Intraduodenal administration, intravenous injection
Result:Intraduodenal administration: increased the bladder capacity without affecting the MBCP (bladder contraction pressure).Intravenous injection: inhibited the IVBCs (isovolumetric bladder contractions) in a dose-dependent manner without affecting the amplitude.Suppressed the increase in the pelvic afferent discharge frequency and inhibited the increase in intravesical pressure.
NS-8, a pyrrole derivative, activates the Ca2+-sensitive k+-channel. NS-8 can suppress the micturition reflex by decreasing afferent pelvic nerve activity. NS-8 can be used in the research of urinary frequency and incontinence.
体内研究：
NS-8 (intravenous injection or intraduodenal administration, 3 and 10 mg/kg) suppresses the rat micturition reflex by inhibiting afferent pelvic nerve activity in rats.Animal Model:Rats
Dosage:1, 3 and 10 mg/kg
Administration:Intraduodenal administration, intravenous injection
Result:Intraduodenal administration: increased the bladder capacity without affecting the MBCP (bladder contraction pressure).Intravenous injection: inhibited the IVBCs (isovolumetric bladder contractions) in a dose-dependent manner without affecting the amplitude.Suppressed the increase in the pelvic afferent discharge frequency and inhibited the increase in intravesical pressure.
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