产品
编 号：F025960
分子式：C53H100N16O13 (for E1)
分子量：1169.5
分子式：C53H100N16O13 (for E1)
分子量：1169.5
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CAS No: 1066-17-7
产品详情
生物活性：
Colistin (Polymyxin E) is an orally active polypeptide antibiotic. Colistin has excellent activity against various Gram-negative rod-shaped bacteria, including multidrug-resistant Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae. Colistin is associated with nephrotoxicity. Colistin can be used for the research of infections caused by Gram-negative bacilli.
体内研究：
Colistin (Polymyxin E) (16 mg/kg/day, i.p.) shows the enrichment of cell cycle arrest genes andsuggests that injury or cellular stress caused by colistin is acting through p53 to inhibit cell cycle progression.Colistin (16 mg/kg/day, i.p.) has elevated blood urea nitrogen (BUN), creatinine, and pathologic evidence of acute tubular necrosis and apoptosis.Animal Model:C57/BL6 mice
Dosage:16 mg/kg/day
Administration:16 mg/kg/day, i.p.
Result:Detected apoptosis, necrosis PCNA staining in mice.
Colistin (Polymyxin E) is an orally active polypeptide antibiotic. Colistin has excellent activity against various Gram-negative rod-shaped bacteria, including multidrug-resistant Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae. Colistin is associated with nephrotoxicity. Colistin can be used for the research of infections caused by Gram-negative bacilli.
体内研究：
Colistin (Polymyxin E) (16 mg/kg/day, i.p.) shows the enrichment of cell cycle arrest genes andsuggests that injury or cellular stress caused by colistin is acting through p53 to inhibit cell cycle progression.Colistin (16 mg/kg/day, i.p.) has elevated blood urea nitrogen (BUN), creatinine, and pathologic evidence of acute tubular necrosis and apoptosis.Animal Model:C57/BL6 mice
Dosage:16 mg/kg/day
Administration:16 mg/kg/day, i.p.
Result:Detected apoptosis, necrosis PCNA staining in mice.
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