产品
编 号：F025954
分子式：C151H228N40O47
分子量：3355.67
分子式：C151H228N40O47
分子量：3355.67
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规格
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是否有货
1mg
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5mg
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10mg
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25mg
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CAS No: 106612-94-6
产品详情
生物活性：
GLP-1(7-37) is an intestinal insulinotropic hormone that augments glucose induced insulin secretion.
体内研究：
GLP-1(7-37) (0.5, 5 or 50 pmol/min/kg) infused during the second hour of a 2-hour 11-mM hyperglycemic clamp produces a dose-related enhancement of the glucose-stimulated increase in plasma insulin concentration and an increased rate of glucose infusion in rats.Infusion of GLP-1(7-37) (5 pmol/min/kg) from 1 hour through 7 hours produces a sustained increase in plasma insulin concentration relative to levels in rats infused with vehicle in rats with maintained glucose concentration at 11 mM.Animal Model:Male Sprague-Dawley rats weighing 300 to 350 g with maintained plasma glucose concentration at 11 mM.
Dosage:0.5, 5 or 50 pmol/min/kg.
Administration:IV during the second hour of a 2-hour 11-mmol/L hyperglycemic clamp.
Result:Produced a dose-related enhancement of the glucose-stimulated increase in plasma insulin concentration and an increased rate of glucose infusion.
Animal Model:Male Sprague-Dawley rats weighing 300 to 350 g with glucose IV at a variablerate for 7 hours to maintain plasma glucose concentration at 11 mM.
Dosage:5 pmol/min/kg.
Administration:IV from 1 hour through 7 hours.
Result:Produced a sustained increase in plasma insulin concentration relative to levels in rats infused with vehicle.
GLP-1(7-37) is an intestinal insulinotropic hormone that augments glucose induced insulin secretion.
体内研究：
GLP-1(7-37) (0.5, 5 or 50 pmol/min/kg) infused during the second hour of a 2-hour 11-mM hyperglycemic clamp produces a dose-related enhancement of the glucose-stimulated increase in plasma insulin concentration and an increased rate of glucose infusion in rats.Infusion of GLP-1(7-37) (5 pmol/min/kg) from 1 hour through 7 hours produces a sustained increase in plasma insulin concentration relative to levels in rats infused with vehicle in rats with maintained glucose concentration at 11 mM.Animal Model:Male Sprague-Dawley rats weighing 300 to 350 g with maintained plasma glucose concentration at 11 mM.
Dosage:0.5, 5 or 50 pmol/min/kg.
Administration:IV during the second hour of a 2-hour 11-mmol/L hyperglycemic clamp.
Result:Produced a dose-related enhancement of the glucose-stimulated increase in plasma insulin concentration and an increased rate of glucose infusion.
Animal Model:Male Sprague-Dawley rats weighing 300 to 350 g with glucose IV at a variablerate for 7 hours to maintain plasma glucose concentration at 11 mM.
Dosage:5 pmol/min/kg.
Administration:IV from 1 hour through 7 hours.
Result:Produced a sustained increase in plasma insulin concentration relative to levels in rats infused with vehicle.
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