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编 号：F231140
分子式：C21H30N4O5S
分子量：450.55
分子式：C21H30N4O5S
分子量：450.55
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CAS No: 185106-16-5
产品详情
生物活性：
Acotiamide is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with an IC50 of 1.79 μM. Acotiamide can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory.
体内研究：
Acotiamide (0.3, 1, 3 mg/kg; i.v./3, 10, 30 mg/kg; p.o.) increases the postprandial gastric motility index in a dose-dependent manner.Acotiamide (0.83 mg/kg; i.v.; once) inhibits AChE in rat stomach with an IC50 value of 1.79 μM.Animal Model:Male mongrel dogs (9-11 kg), Male beagle dogs (9.6-12.9 kg)
Dosage:0.3, 1, 3, 10, 30 mg/kg
Administration:Intravenous injection; once
Result:Increased the postprandial gastric motility.
Animal Model:Male Sprague-Dawley rats (aged 6-7 weeks)
Dosage:0.83 mg/kg
Administration:Intravenous injection; once.
Result:Effectively improved functional dyspepsia by inhibiting AChE in rat stomach.
体外研究：
Acotiamide (10, 30, 100 μM; 1 hour) reduces expression levels of IκB-α phosphorylation in LPS- and MCP-1-stimulated macrophage cell lines.
Acotiamide is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with an IC50 of 1.79 μM. Acotiamide can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory.
体内研究：
Acotiamide (0.3, 1, 3 mg/kg; i.v./3, 10, 30 mg/kg; p.o.) increases the postprandial gastric motility index in a dose-dependent manner.Acotiamide (0.83 mg/kg; i.v.; once) inhibits AChE in rat stomach with an IC50 value of 1.79 μM.Animal Model:Male mongrel dogs (9-11 kg), Male beagle dogs (9.6-12.9 kg)
Dosage:0.3, 1, 3, 10, 30 mg/kg
Administration:Intravenous injection; once
Result:Increased the postprandial gastric motility.
Animal Model:Male Sprague-Dawley rats (aged 6-7 weeks)
Dosage:0.83 mg/kg
Administration:Intravenous injection; once.
Result:Effectively improved functional dyspepsia by inhibiting AChE in rat stomach.
体外研究：
Acotiamide (10, 30, 100 μM; 1 hour) reduces expression levels of IκB-α phosphorylation in LPS- and MCP-1-stimulated macrophage cell lines.
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