产品
编 号：F231132
分子式：C21H31ClN4O5S
分子量：487.01
分子式：C21H31ClN4O5S
分子量：487.01
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CAS No: 185104-11-4
产品详情
生物活性：
Acotiamide hydrochloride is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with an IC50 of 1.79 μM. Acotiamide hydrochloride can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide hydrochloride has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory.
体内研究：
Acotiamide hydrochloride (0.3, 1, 3 mg/kg; i.v./3, 10, 30 mg/kg; p.o.) increases the postprandial gastric motility index in a dose-dependent manner.Acotiamide hydrochloride (0.83 mg/kg; i.v.; once) inhibits AChE in rat stomach with an IC50 value of 1.79 μM.Animal Model:Male mongrel dogs (9-11 kg), Male beagle dogs (9.6-12.9 kg)
Dosage:0.3, 1, 3, 10, 30 mg/kg
Administration:Intravenous injection; once.
Result:Increased the postprandial gastric motility.
Animal Model:Male Sprague-Dawley rats (aged 6-7 weeks).
Dosage:0.83 mg/kg
Administration:Intravenous injection; once.
Result:Effectively improved functional dyspepsia by inhibiting AChE in rat stomach.
体外研究：
Acotiamide hydrochloride (10, 30, 100 μM; 1 hour) reduces expression levels of IκB-α phosphorylation in LPS- and MCP-1-stimulated macrophage cell lines.
Acotiamide hydrochloride is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with an IC50 of 1.79 μM. Acotiamide hydrochloride can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide hydrochloride has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory.
体内研究：
Acotiamide hydrochloride (0.3, 1, 3 mg/kg; i.v./3, 10, 30 mg/kg; p.o.) increases the postprandial gastric motility index in a dose-dependent manner.Acotiamide hydrochloride (0.83 mg/kg; i.v.; once) inhibits AChE in rat stomach with an IC50 value of 1.79 μM.Animal Model:Male mongrel dogs (9-11 kg), Male beagle dogs (9.6-12.9 kg)
Dosage:0.3, 1, 3, 10, 30 mg/kg
Administration:Intravenous injection; once.
Result:Increased the postprandial gastric motility.
Animal Model:Male Sprague-Dawley rats (aged 6-7 weeks).
Dosage:0.83 mg/kg
Administration:Intravenous injection; once.
Result:Effectively improved functional dyspepsia by inhibiting AChE in rat stomach.
体外研究：
Acotiamide hydrochloride (10, 30, 100 μM; 1 hour) reduces expression levels of IκB-α phosphorylation in LPS- and MCP-1-stimulated macrophage cell lines.
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