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编 号:F230807
分子式:C21H23FN6O6S
分子量:506.51
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10mM*1mL in DMSO
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5mg
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10mg
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25mg
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生物活性:
TAS4464 is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE), with an IC50 of 0.955 nM.

体外研究:
TAS4464 treatment inhibits cullin neddylation and subsequently induces the accumulation of CRL substrates such as CDT1, p27, and phosphorylates IκBα in 47 human cancer cell lines.
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