产品
编 号：F230692
分子式：C34H54Cl2N10O14
分子量：897.76
分子式：C34H54Cl2N10O14
分子量：897.76
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价格
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CAS No: 18472-51-0
产品详情
生物活性：
Chlorhexidine digluconate is a chlorophenyl biguanide with broad antibacterial action against both Gram (+) and (-) bacteria and fungi. Chlorhexidine digluconate is a broad-spectrum antiseptic and disinfectant. Chlorhexidine digluconate is effective to prevent and control infectious diseases of the mouth by killing bacteria in saliva and tongue. Chlorhexidine digluconate is a cytotoxic agent and induces cell necrosis and apoptosis.
体内研究：
Chlorhexidine gluconate (0.05%、0.025%；一次性腹腔注射) 与仅用生理盐水灌洗的小鼠相比，0.05% 的浓度可以显着降低灌洗术后腹内脓肿发生率。Animal Model:Male Imprinting Control Region (ICR) mice at 6 to 8-wk-old (body weight, 25g)
Dosage:Chlorhexidine gluconate 0.05% and 0.025%
Administration:One-time intraperitoneal injection
Result:With 0.05% lavage had significantly lower incidence of postoperative intra-abdominal abscesses compared with the mice that had saline lavage only.
体外研究：
Chlorhexidine digluconate (0.00001%、0.00005%、0.0001%、0.0005%；1-4 小时) 对 CHO 细胞具有细胞毒性作用。Chlorhexidine digluconate 以剂量依赖性和时间依赖性的方式降低 CHO 细胞脱氢酶的活性。Chlorhexidine digluconate (0.00005%、0.0001%、0.0005%；1 小时) 分别引起约 1.62%、5.51% 和 5.47% 的细胞凋亡量，细胞坏死量分别为 2.38%、8.62%、22.50%。
Chlorhexidine digluconate is a chlorophenyl biguanide with broad antibacterial action against both Gram (+) and (-) bacteria and fungi. Chlorhexidine digluconate is a broad-spectrum antiseptic and disinfectant. Chlorhexidine digluconate is effective to prevent and control infectious diseases of the mouth by killing bacteria in saliva and tongue. Chlorhexidine digluconate is a cytotoxic agent and induces cell necrosis and apoptosis.
体内研究：
Chlorhexidine gluconate (0.05%、0.025%；一次性腹腔注射) 与仅用生理盐水灌洗的小鼠相比，0.05% 的浓度可以显着降低灌洗术后腹内脓肿发生率。Animal Model:Male Imprinting Control Region (ICR) mice at 6 to 8-wk-old (body weight, 25g)
Dosage:Chlorhexidine gluconate 0.05% and 0.025%
Administration:One-time intraperitoneal injection
Result:With 0.05% lavage had significantly lower incidence of postoperative intra-abdominal abscesses compared with the mice that had saline lavage only.
体外研究：
Chlorhexidine digluconate (0.00001%、0.00005%、0.0001%、0.0005%；1-4 小时) 对 CHO 细胞具有细胞毒性作用。Chlorhexidine digluconate 以剂量依赖性和时间依赖性的方式降低 CHO 细胞脱氢酶的活性。Chlorhexidine digluconate (0.00005%、0.0001%、0.0005%；1 小时) 分别引起约 1.62%、5.51% 和 5.47% 的细胞凋亡量，细胞坏死量分别为 2.38%、8.62%、22.50%。
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