产品
编 号：F002770
分子式：C7H8O
分子量：108.14
分子式：C7H8O
分子量：108.14
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
400
In-stock
结构图
CAS No: 100-51-6
产品详情
生物活性：
Benzyl alcohol is an aromatic alcohol, a colorless liquid with a mild aromatic odor. Benzyl alcohol is an inhibitor of P450 enzyme. Benzyl alcohol mediated Toll-Like Receptor 4 to reduce the inflammatory response of liver injury in mice.
体内研究：
苯甲醇 (270 mg/kg, 腹腔注射, 0.5-24 h) 可减轻对乙酰氨基酚 (HY-66005) 引起的肝损伤。苯甲醇 (270 mg/kg, 腹腔注射, 3-24 h) 通过 TLR4 依赖的方式降低炎性体的激活。Animal Model:APAP-induced liver injury model in mice
Dosage:270 mg/kg
Administration:i.p.
Result:Attenuated the increase in ALT activities and reduced areas of necrosis at both 6 h and 24 h.Reduced APAP metabolic activation and parameters of oxidant stress.Reduced APAP-induced mitochondrial dysfunction.
体外研究：
苯甲醇 (10-80 mM) 在 MDCK 细胞中通过增加完整肾上皮细胞的膜流动性调节环 AMP 合成。苯甲醇 (0-46 mM, 48 h) 通过抑制小鼠原代肝中细胞色素 P450 酶活性来抑制 APAP (HY-66005) 肝毒性。
Benzyl alcohol is an aromatic alcohol, a colorless liquid with a mild aromatic odor. Benzyl alcohol is an inhibitor of P450 enzyme. Benzyl alcohol mediated Toll-Like Receptor 4 to reduce the inflammatory response of liver injury in mice.
体内研究：
苯甲醇 (270 mg/kg, 腹腔注射, 0.5-24 h) 可减轻对乙酰氨基酚 (HY-66005) 引起的肝损伤。苯甲醇 (270 mg/kg, 腹腔注射, 3-24 h) 通过 TLR4 依赖的方式降低炎性体的激活。Animal Model:APAP-induced liver injury model in mice
Dosage:270 mg/kg
Administration:i.p.
Result:Attenuated the increase in ALT activities and reduced areas of necrosis at both 6 h and 24 h.Reduced APAP metabolic activation and parameters of oxidant stress.Reduced APAP-induced mitochondrial dysfunction.
体外研究：
苯甲醇 (10-80 mM) 在 MDCK 细胞中通过增加完整肾上皮细胞的膜流动性调节环 AMP 合成。苯甲醇 (0-46 mM, 48 h) 通过抑制小鼠原代肝中细胞色素 P450 酶活性来抑制 APAP (HY-66005) 肝毒性。
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