产品
编 号：F230405
分子式：C9H12FN3O3S
分子量：261.27
分子式：C9H12FN3O3S
分子量：261.27
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CAS No: 184302-49-6
产品详情
生物活性：
FF-10502, a structural analog of Gemcitabine, is a pyrimidine nucleoside antimetabolite. FF-10502 inhibits DNA polymerase α and β. FF-10502 shows beneficial anticancer activity via a mechanism of action on dormant cells.
体内研究：
FF-10502 (120-480 mg/kg; i.v; once weekly; for 4 weeks) shows an antitumor effect in a mouse xenograft model with the subcutaneously implanted human pancreatic cancer cell line Capan-1.Animal Model:Five-week-old female nude mice (BALB/c-nu/nu) injected with Capan-1 cells.
Dosage:120 mg/kg, 240 mg/kg, 360 mg/kg, and 480 mg/kg
Administration:Tail vein injection; once weekly; for 4 weeks
Result:Suppressed tumor growth in a dose-dependent manner in mice.
体外研究：
FF-10502 (0.1 nM-10 μM; 72 hours) shows the growth inhibition of pancreatic cancer cell lines, with IC50s of 59.9 nM, 39.6 nM, 68.2 nM, and 331.4 nM for BxPC-3, SUIT-2, Capan-1, and MIA PaCa-2 cells, respectively.
FF-10502, a structural analog of Gemcitabine, is a pyrimidine nucleoside antimetabolite. FF-10502 inhibits DNA polymerase α and β. FF-10502 shows beneficial anticancer activity via a mechanism of action on dormant cells.
体内研究：
FF-10502 (120-480 mg/kg; i.v; once weekly; for 4 weeks) shows an antitumor effect in a mouse xenograft model with the subcutaneously implanted human pancreatic cancer cell line Capan-1.Animal Model:Five-week-old female nude mice (BALB/c-nu/nu) injected with Capan-1 cells.
Dosage:120 mg/kg, 240 mg/kg, 360 mg/kg, and 480 mg/kg
Administration:Tail vein injection; once weekly; for 4 weeks
Result:Suppressed tumor growth in a dose-dependent manner in mice.
体外研究：
FF-10502 (0.1 nM-10 μM; 72 hours) shows the growth inhibition of pancreatic cancer cell lines, with IC50s of 59.9 nM, 39.6 nM, 68.2 nM, and 331.4 nM for BxPC-3, SUIT-2, Capan-1, and MIA PaCa-2 cells, respectively.
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