产品
编 号：F025699
分子式：C24H26ClFN4O
分子量：440.94
分子式：C24H26ClFN4O
分子量：440.94
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
50mg
询价
询价
结构图
CAS No: 106516-24-9
产品详情
生物活性：
Sertindole (Lu 23-174) is an orally active 5-HT2A, 5-HT2C, dopamine D2, and αl-adrenergic receptors antagonist. Sertindole shows antipsychotic activity and anti-proliferative activity to multiple cancer cells.
体内研究：
Sertindole (oral gavage; 10?mg/kg; once daily; 12 d) shows anti-tumor activity in vivo.Animal Model:Immune-deficient Balb/c mice implanted MDA-MB-231 human TNBC cells
Dosage:10?mg/kg
Administration:Oral gavage; 10?mg/kg; once daily; 12 days
Result:Exhibited a 22.7% reduction in size after a 12-day administration regimen.
体外研究：
Sertindole (0-100 μM; 48 h) attenuates proliferation of breast cancer cells.Sertindole (0.8-27.6 μM; 48 h) inhibits proliferation toward many cancers in vitro.Sertindole (5?μΜ and 10 μΜ; 24 h) attenuates migration of breast cancer cells.
Sertindole (Lu 23-174) is an orally active 5-HT2A, 5-HT2C, dopamine D2, and αl-adrenergic receptors antagonist. Sertindole shows antipsychotic activity and anti-proliferative activity to multiple cancer cells.
体内研究：
Sertindole (oral gavage; 10?mg/kg; once daily; 12 d) shows anti-tumor activity in vivo.Animal Model:Immune-deficient Balb/c mice implanted MDA-MB-231 human TNBC cells
Dosage:10?mg/kg
Administration:Oral gavage; 10?mg/kg; once daily; 12 days
Result:Exhibited a 22.7% reduction in size after a 12-day administration regimen.
体外研究：
Sertindole (0-100 μM; 48 h) attenuates proliferation of breast cancer cells.Sertindole (0.8-27.6 μM; 48 h) inhibits proliferation toward many cancers in vitro.Sertindole (5?μΜ and 10 μΜ; 24 h) attenuates migration of breast cancer cells.
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