产品
编 号：F227063
分子式：C11H11NO3
分子量：205.21
纯 度：99.5%
分子式：C11H11NO3
分子量：205.21
纯 度：99.5%
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
616
In-stock
5mg
350
In-stock
10mg
560
In-stock
25mg
780
In-stock
50mg
1260
In-stock
100mg
2142
In-stock
结构图
CAS No: 1821-52-9
产品详情
生物活性：
Indolelactic acid (Indole-3-lactic acid) is a tryptophan (Trp) catabolite in Azotobacter vinelandii cultures. Indolelactic acid has anti-inflammation and potential anti-viral activity.
体内研究：
Indolelactic acid (gavage feeding, 10 μM, 5 μL, 5 days, C57BL/6 mice) benefits the immature intestine preferentially.Animal Model:C57BL/6 mice
Dosage:10 μM, 5 μL
Administration:Gavage feeding, 5 days
Result:Upregulated the innate immune response genes in immature mouse intestine (C57-pup-ileum), with no effects on pup-colon or adult intestine.
体外研究：
Indolelactic acid (1 mM, 5 days) upregulates CXCR3, granzyme B, and immunoregulatory galectin-1 in Th2 cells.Indolelactic acid (0.1-10 mM, 1 h) significantly inhibits LPS-induced inflammation in RAW blue macrophages and Caco-2 cells. Indolelactic acid (0.1-10 mM, 1 h) inhibits TNF-α induced inflammation in HT-29 cells. Indolelactic acid (10 mM, 1 h) activates the AhR and downstream Nrf2 pathway in Caco-2 cells.Indolelactic acid (5 μM, 24 h) enhances the IFIT2 and RSAD2 mRNA expression in H4 cells stimulated by IL-1β.
Indolelactic acid (Indole-3-lactic acid) is a tryptophan (Trp) catabolite in Azotobacter vinelandii cultures. Indolelactic acid has anti-inflammation and potential anti-viral activity.
体内研究：
Indolelactic acid (gavage feeding, 10 μM, 5 μL, 5 days, C57BL/6 mice) benefits the immature intestine preferentially.Animal Model:C57BL/6 mice
Dosage:10 μM, 5 μL
Administration:Gavage feeding, 5 days
Result:Upregulated the innate immune response genes in immature mouse intestine (C57-pup-ileum), with no effects on pup-colon or adult intestine.
体外研究：
Indolelactic acid (1 mM, 5 days) upregulates CXCR3, granzyme B, and immunoregulatory galectin-1 in Th2 cells.Indolelactic acid (0.1-10 mM, 1 h) significantly inhibits LPS-induced inflammation in RAW blue macrophages and Caco-2 cells. Indolelactic acid (0.1-10 mM, 1 h) inhibits TNF-α induced inflammation in HT-29 cells. Indolelactic acid (10 mM, 1 h) activates the AhR and downstream Nrf2 pathway in Caco-2 cells.Indolelactic acid (5 μM, 24 h) enhances the IFIT2 and RSAD2 mRNA expression in H4 cells stimulated by IL-1β.
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