产品
编 号：F226925
分子式：C24H24FN3O3
分子量：421.46
分子式：C24H24FN3O3
分子量：421.46
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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5mg
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10mg
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50mg
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100mg
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结构图
CAS No: 1820812-16-5
产品详情
生物活性：
TAK-071 is a novel, potent and highly selective muscarinic acetylcholine receptor 1 (M1R) positive allosteric modulator. EC50 of TAK-071 M1R agonist activities is 520 nM.
体内研究：
TAK-071 increase hippocampal inositol monophosphate production through M1R activation and improved DB00747-induced cognitive deficits in rats at 0.3 mg/kg. TAK-071 also induce diarrhea at 10 mg/kg in rats.Combining sub-effective doses of TAK-071 (3 mg/kg) with an acetylcholinesterase inhibitor significantly ameliorates DB00747-induced cognitive deficits in rats.
TAK-071 is a novel, potent and highly selective muscarinic acetylcholine receptor 1 (M1R) positive allosteric modulator. EC50 of TAK-071 M1R agonist activities is 520 nM.
体内研究：
TAK-071 increase hippocampal inositol monophosphate production through M1R activation and improved DB00747-induced cognitive deficits in rats at 0.3 mg/kg. TAK-071 also induce diarrhea at 10 mg/kg in rats.Combining sub-effective doses of TAK-071 (3 mg/kg) with an acetylcholinesterase inhibitor significantly ameliorates DB00747-induced cognitive deficits in rats.
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