产品
编 号:F225686
分子式:C42H70O12
分子量:767
产品类型
结构图
CAS No: 181225-33-2
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产品详情
生物活性:
Ginsenoside F4 (GF4), ginseng saponinis, isolated from notoginseng or red ginseng. Ginsenoside F4 (GF4) has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis.Ginsenoside F4 (GF4) inhibits matrix metalloproteinase 13 (MMP 13) expression in IL-1β-treated chondrocytes and blocks cartilage breakdown in rabbit cartilage tissue culture, shows therapeutic potential for preventing cartilage collagen matrix breakdown in diseased tissues.
体外研究:
Ginsenoside F4 抑制 JK 细胞增殖的 IC50 值为 87.74 μM。Ginsenoside F4 (8.15-130.38 μM) 在人淋巴细胞瘤 JK 细胞中增加 Bax 表达而降低 Bcl-2 表达,效力呈剂量依赖性。Ginsenoside F4 (8.15-130.38 μM) 诱导人淋巴细胞瘤 JK 细胞凋亡而显示抗肿瘤活性。