产品
编 号：F225603
分子式：C13H11N3.1/2H2SO4
分子量：258.28
分子式：C13H11N3.1/2H2SO4
分子量：258.28
产品类型
规格
价格
是否有货
100mg
400
In-stock
结构图
CAS No: 1811-28-5
产品详情
生物活性：
Proflavine hemisulfate, an acridine dye, is a known DNA intercalating agent. Anti-microbial agent. Proflavine hemisulfate behaves as a pore blocker for Kir3.2. Proflavine hemisulfate is a potential lead compound for Kir3.2-associated neurological diseases.
体内研究：
The concentrations of Proflavine (20 mg/kg) in whole blood after intravenous injection decreased rapidly at the beginning and remained stable from around 30 min after dosing.Animal Model:Adult male Sprague Dawley rats (weighing approximately 200 g)
Dosage:20 mg/kg (Pharmacokinetic Analysis)
Administration:Intravenous injection; 2, 4, 5, 10, 15, 20, 25, and 30 min after dosing
Result:Concentration decreased rapidly from whole blood in the first 5 min after dosing, followed by a slower decrease.
体外研究：
Proflavine (0.1-10 μM; 24 hours) inhibits the growth of Kir3.2-transformant cells and Kir3.2 activity in a concentration-dependent manner. Proflavine (300 μM) progressively reduces the current amplitude of Kir3.2 mutant to 27.7±4.3% of the control.
Proflavine hemisulfate, an acridine dye, is a known DNA intercalating agent. Anti-microbial agent. Proflavine hemisulfate behaves as a pore blocker for Kir3.2. Proflavine hemisulfate is a potential lead compound for Kir3.2-associated neurological diseases.
体内研究：
The concentrations of Proflavine (20 mg/kg) in whole blood after intravenous injection decreased rapidly at the beginning and remained stable from around 30 min after dosing.Animal Model:Adult male Sprague Dawley rats (weighing approximately 200 g)
Dosage:20 mg/kg (Pharmacokinetic Analysis)
Administration:Intravenous injection; 2, 4, 5, 10, 15, 20, 25, and 30 min after dosing
Result:Concentration decreased rapidly from whole blood in the first 5 min after dosing, followed by a slower decrease.
体外研究：
Proflavine (0.1-10 μM; 24 hours) inhibits the growth of Kir3.2-transformant cells and Kir3.2 activity in a concentration-dependent manner. Proflavine (300 μM) progressively reduces the current amplitude of Kir3.2 mutant to 27.7±4.3% of the control.
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