产品
编 号：F225319
分子式：C33H42ClN3O7S
分子量：660.22
分子式：C33H42ClN3O7S
分子量：660.22
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 1809336-93-3
产品详情
生物活性：
Valemetostat (DS-3201) tosylate, a first-in-class EZH1/2 dual inhibitor with IC50 values ＜10 nM. Valemetostat tosylate can be used for the research of relapsed/refractory peripheral T-cell lymphoma.
体内研究：
Valemetostat tosylate (0.01 mg/g; i.p.; once) 可防止运动训练后 H3K27me3 的变化。Animal Model:Male C57BL/6J mice with chronic and acute running exercise or without exercise
Dosage:0.01 mg/g
Administration:Intraperitoneal injection; 0.01 mg/g; 30 min before the start of running exercise
Result:Significantly increased the level of H3K27me3 , slightly decresed EZH1 level , upregulated the EZH2 level and increased the level of phosphorylated AMPK after exercise. Repressed myonuclear H3K27me3 accumulation during training and caused a failure of adaptive changes.
体外研究：
Valemetostat tosylate (1-1000 nM) 强烈且特异地抑制 EZH1 和 EZH2，IC50 值 Valemetostat tosylate 相关抗体:
Valemetostat (DS-3201) tosylate, a first-in-class EZH1/2 dual inhibitor with IC50 values ＜10 nM. Valemetostat tosylate can be used for the research of relapsed/refractory peripheral T-cell lymphoma.
体内研究：
Valemetostat tosylate (0.01 mg/g; i.p.; once) 可防止运动训练后 H3K27me3 的变化。Animal Model:Male C57BL/6J mice with chronic and acute running exercise or without exercise
Dosage:0.01 mg/g
Administration:Intraperitoneal injection; 0.01 mg/g; 30 min before the start of running exercise
Result:Significantly increased the level of H3K27me3 , slightly decresed EZH1 level , upregulated the EZH2 level and increased the level of phosphorylated AMPK after exercise. Repressed myonuclear H3K27me3 accumulation during training and caused a failure of adaptive changes.
体外研究：
Valemetostat tosylate (1-1000 nM) 强烈且特异地抑制 EZH1 和 EZH2，IC50 值 Valemetostat tosylate 相关抗体:
产品资料
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