产品
编 号：F225216
分子式：C26H30ClN3O4S
分子量：516.05
分子式：C26H30ClN3O4S
分子量：516.05
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CAS No: 1808948-28-8
产品详情
生物活性：
(2S,3R)-LP99 is a potent and selective BRD7 and BRD9 inhibitor with an KD of 99 nM for BRD9. (2S,3R)-LP99 inhibits the association of BRD7 and BRD9 to acetylated histones in vitro and in cells. (2S,3R)-LP99 demonstrates that BRD7/9 plays a role in regulating pro-inflammatory cytokine secretion.
体外研究：
(2S,3R)-LP99 (compound 60) (0-100 μM) inhibits the expression of IL6 in LPS-stimulated (100 ng/mL) THP-1 cells.
(2S,3R)-LP99 is a potent and selective BRD7 and BRD9 inhibitor with an KD of 99 nM for BRD9. (2S,3R)-LP99 inhibits the association of BRD7 and BRD9 to acetylated histones in vitro and in cells. (2S,3R)-LP99 demonstrates that BRD7/9 plays a role in regulating pro-inflammatory cytokine secretion.
体外研究：
(2S,3R)-LP99 (compound 60) (0-100 μM) inhibits the expression of IL6 in LPS-stimulated (100 ng/mL) THP-1 cells.
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