产品
编 号：F223111
分子式：C27H43NO3
分子量：429.64
分子式：C27H43NO3
分子量：429.64
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
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询价
结构图
CAS No: 18059-10-4
产品详情
生物活性：
Peiminine is a compound that can be isolated from Bolbostemma paniculatum (Maxim) Franquet (Cucurbitaceae family). Peiminine can induce apoptosis in human hepatocellular carcinoma HepG2 cells through both extrinsic and intrinsic apoptotic pathways. Peiminine has anti-inflammatory, anticancer, anti-osteoporosis, cardioprotective and other activities in many animal models.
体内研究：
Peiminine (3mg/kg, intraperitoneal injection, single dose) 可减轻溃疡性结肠炎实验模型的炎症表现，减轻肠组织损伤。Peiminine (10 mg/kg, Intraperitoneal injection, once every 2 days for 6 weeks) 可预防 OVX 诱导的大鼠骨量丢失和脂肪形成。Peiminine (1-5 mg/kg, are applied to the dorsal skin, once daily for 16 days) 抑制血清中的 IL-6 和 TNF-α 在 DNCB 诱导的过敏性皮炎动物模型中。Peiminine (2-5 mg/kg, Intraperitoneal injection, once a day for 4 weeks) 对心肌梗死大鼠心肌损伤和纤维化具有保护作用。Peiminine (1-5 mg/kg, Intraperitoneal injection, single dose) 可在脂多糖诱导的急性肺损伤模型小鼠中减轻炎症反应对机体的损伤和肺水肿的可能性。Animal Model:ulcerative colitis model
Dosage:3mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Reduced inflammation, mucosal ulcers, involvement of digestive system layers, and infltration of inflammatory cells.Reduced the levels of MPO and NO generated in the rectal tissue.Reduced cell proliferation in spleen cell.Decreased the production of f IL-1β, IL-6, and TNF-α cytokines.Reduced expression levels of genes IL-1β, IL-6, TNF-α, iNOS, and COX2.
Animal Model:Ovariectomized (OVX) rat model
Dosage:10 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Alleviated the bone loss caused by surgical castration.Improved the expression of COL1A1 and β-catenin and reduced the increase expression of PPAR-γ in trabecular bone.
Animal Model:Allergic dermatitis model
Dosage:1 mg/kg, 5 mg/kg
Administration:were applied to the dorsal skin
Result:Alleviated the bone loss caused by surgical castration.Improved the expression of COL1A1 and β-catenin and reduced the increase expression of PPAR-γ in trabecular bone.
体外研究：
Peiminine (2-6 μg/mL, 24 h) 可降低 HepG2 细胞中 procaspase-3、procaspase- 8、procaspase -9 的表达，提高 caspase-3、8、9 蛋白水平。Peiminine (2-14 μg/mL, 24-72 h) 对 HepG2、Hela、SW480 和 MCF-7 细胞有明显的细胞毒性作用。Peiminine (2-6 μg/mL, 24 h) 诱导 HepG2 细胞凋亡。Peiminine (2-6 μg/mL, 24 h) 诱导 HepG2 细胞阻滞于 G2/M 期。
Peiminine is a compound that can be isolated from Bolbostemma paniculatum (Maxim) Franquet (Cucurbitaceae family). Peiminine can induce apoptosis in human hepatocellular carcinoma HepG2 cells through both extrinsic and intrinsic apoptotic pathways. Peiminine has anti-inflammatory, anticancer, anti-osteoporosis, cardioprotective and other activities in many animal models.
体内研究：
Peiminine (3mg/kg, intraperitoneal injection, single dose) 可减轻溃疡性结肠炎实验模型的炎症表现，减轻肠组织损伤。Peiminine (10 mg/kg, Intraperitoneal injection, once every 2 days for 6 weeks) 可预防 OVX 诱导的大鼠骨量丢失和脂肪形成。Peiminine (1-5 mg/kg, are applied to the dorsal skin, once daily for 16 days) 抑制血清中的 IL-6 和 TNF-α 在 DNCB 诱导的过敏性皮炎动物模型中。Peiminine (2-5 mg/kg, Intraperitoneal injection, once a day for 4 weeks) 对心肌梗死大鼠心肌损伤和纤维化具有保护作用。Peiminine (1-5 mg/kg, Intraperitoneal injection, single dose) 可在脂多糖诱导的急性肺损伤模型小鼠中减轻炎症反应对机体的损伤和肺水肿的可能性。Animal Model:ulcerative colitis model
Dosage:3mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Reduced inflammation, mucosal ulcers, involvement of digestive system layers, and infltration of inflammatory cells.Reduced the levels of MPO and NO generated in the rectal tissue.Reduced cell proliferation in spleen cell.Decreased the production of f IL-1β, IL-6, and TNF-α cytokines.Reduced expression levels of genes IL-1β, IL-6, TNF-α, iNOS, and COX2.
Animal Model:Ovariectomized (OVX) rat model
Dosage:10 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Alleviated the bone loss caused by surgical castration.Improved the expression of COL1A1 and β-catenin and reduced the increase expression of PPAR-γ in trabecular bone.
Animal Model:Allergic dermatitis model
Dosage:1 mg/kg, 5 mg/kg
Administration:were applied to the dorsal skin
Result:Alleviated the bone loss caused by surgical castration.Improved the expression of COL1A1 and β-catenin and reduced the increase expression of PPAR-γ in trabecular bone.
体外研究：
Peiminine (2-6 μg/mL, 24 h) 可降低 HepG2 细胞中 procaspase-3、procaspase- 8、procaspase -9 的表达，提高 caspase-3、8、9 蛋白水平。Peiminine (2-14 μg/mL, 24-72 h) 对 HepG2、Hela、SW480 和 MCF-7 细胞有明显的细胞毒性作用。Peiminine (2-6 μg/mL, 24 h) 诱导 HepG2 细胞凋亡。Peiminine (2-6 μg/mL, 24 h) 诱导 HepG2 细胞阻滞于 G2/M 期。
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