产品
编 号：F222292
分子式：C33H39Cl2N5O5S
分子量：688.66
分子式：C33H39Cl2N5O5S
分子量：688.66
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 1804978-82-2
产品详情
生物活性：
YNT-185 dihydrochloride is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC50s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 dihydrochloride ameliorates narcolepsy-cataplexy symptoms in mouse models.
体内研究：
YNT-185 dihydrochloride (20-40 mg/kg; i.p.) increases wakefulness in mice.YNT-185 dihydrochloride (300 nmol; i.c.v.) significantly increases wake time for 3 hours in a dose-dependent manner, accompanied by a decrease in NREM sleep time, in wild-type mice but not in OXRDKO mice.Animal Model:Male wild-type C57BL/6J mice
Dosage:20, 40 mg/kg
Administration:I.p.
Result:Wake time was also significantly increased.
YNT-185 dihydrochloride is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC50s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 dihydrochloride ameliorates narcolepsy-cataplexy symptoms in mouse models.
体内研究：
YNT-185 dihydrochloride (20-40 mg/kg; i.p.) increases wakefulness in mice.YNT-185 dihydrochloride (300 nmol; i.c.v.) significantly increases wake time for 3 hours in a dose-dependent manner, accompanied by a decrease in NREM sleep time, in wild-type mice but not in OXRDKO mice.Animal Model:Male wild-type C57BL/6J mice
Dosage:20, 40 mg/kg
Administration:I.p.
Result:Wake time was also significantly increased.
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