产品
编 号：F221746
分子式：C25H23N9O6S
分子量：577.57
分子式：C25H23N9O6S
分子量：577.57
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
结构图
CAS No: 180384-56-9
产品详情
生物活性：
Clazosentan (Ro 61-1790) is a selective endothelin A (ETA) receptor antagonist. Clazosentan inhibits ET-1-mediated vasoconstriction. Clazosentan prevents cerebral vasospasm, vasospasm-related cerebral infarction.
体内研究：
Clazosentan (10 μM, 0.05?mL/kg, intracisternal injection) inhibits the contractile responses to ET-1 in rats.Clazosentan (10 mg/kg, s.c.) inhibits IL-33-induced hypernociception in mice.Animal Model:Rats
Dosage:10 μM, 0.05?mL/kg
Administration:Intracisternal injection
Result:Inhibited the contractile responses to ET-1, without preventing SAH-induced upregulation of ET receptors in cerebral arteries.
体外研究：
Clazosentan (0.1 μM) inhibits the ETA receptor in cerebral arteries.Clazosentan is a substrate of the organic anion-transporting polypeptide (OATP) 1B1/1B3.
Clazosentan (Ro 61-1790) is a selective endothelin A (ETA) receptor antagonist. Clazosentan inhibits ET-1-mediated vasoconstriction. Clazosentan prevents cerebral vasospasm, vasospasm-related cerebral infarction.
体内研究：
Clazosentan (10 μM, 0.05?mL/kg, intracisternal injection) inhibits the contractile responses to ET-1 in rats.Clazosentan (10 mg/kg, s.c.) inhibits IL-33-induced hypernociception in mice.Animal Model:Rats
Dosage:10 μM, 0.05?mL/kg
Administration:Intracisternal injection
Result:Inhibited the contractile responses to ET-1, without preventing SAH-induced upregulation of ET receptors in cerebral arteries.
体外研究：
Clazosentan (0.1 μM) inhibits the ETA receptor in cerebral arteries.Clazosentan is a substrate of the organic anion-transporting polypeptide (OATP) 1B1/1B3.
产品资料
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