产品
编 号：F218557
分子式：C22H23ClN2O5
分子量：430.88
分子式：C22H23ClN2O5
分子量：430.88
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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结构图
CAS No: 1802997-81-4
产品详情
生物活性：
SEC induces activation of ANXA7 GTPase via the AMPK/mTORC1/STAT3 signaling pathway. SEC selectively promotes apoptosis in cancer cells, expressing a high level of ITGB4 by inducing ITGB4 nuclear translocation.
体内研究：
SEC (3 mg/kg/day or 18 mg/kg/day) suppresses metastasis in PC-3M-Luc orthotopic implantation nude mice model.Animal Model:Luciferase-labeled PC-3M-Luc cells (2×106 per 50 μL sterile HBSS?/?) are orthotopically inoculated into the prostates of 8-week-old nude mice.
Dosage:3 mg/kg/day or 18 mg/kg/day.
Administration:IP daily for 3 weeks.
Result:Suppressed the lymph node metastatic capacities of PC-3M-Luc cells in the nude mice model.Decreased the mRNA level of CCL2, APLN and IL6ST in implanted tumors.Did not affect the body weight of the mice.
体外研究：
SEC (20 μM) inhibits the cell migration of HEK 293T RKIP?/? cells and PC3 prostate cancer cells.SEC (20 μM) significantly increases AMPK phosphorylation in PC3 cells, which is inverted by ANXA7 GTPase specific inhibitor ABO, indicating that activated ANXA7 with enhanced phosphorylation level promotes AMPK phosphorylation (cell selectively).
SEC induces activation of ANXA7 GTPase via the AMPK/mTORC1/STAT3 signaling pathway. SEC selectively promotes apoptosis in cancer cells, expressing a high level of ITGB4 by inducing ITGB4 nuclear translocation.
体内研究：
SEC (3 mg/kg/day or 18 mg/kg/day) suppresses metastasis in PC-3M-Luc orthotopic implantation nude mice model.Animal Model:Luciferase-labeled PC-3M-Luc cells (2×106 per 50 μL sterile HBSS?/?) are orthotopically inoculated into the prostates of 8-week-old nude mice.
Dosage:3 mg/kg/day or 18 mg/kg/day.
Administration:IP daily for 3 weeks.
Result:Suppressed the lymph node metastatic capacities of PC-3M-Luc cells in the nude mice model.Decreased the mRNA level of CCL2, APLN and IL6ST in implanted tumors.Did not affect the body weight of the mice.
体外研究：
SEC (20 μM) inhibits the cell migration of HEK 293T RKIP?/? cells and PC3 prostate cancer cells.SEC (20 μM) significantly increases AMPK phosphorylation in PC3 cells, which is inverted by ANXA7 GTPase specific inhibitor ABO, indicating that activated ANXA7 with enhanced phosphorylation level promotes AMPK phosphorylation (cell selectively).
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