产品
编 号：F218423
分子式：C21H32N6O3
分子量：416.52
分子式：C21H32N6O3
分子量：416.52
产品类型
规格
价格
是否有货
1mg
询价
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 1802088-50-1
产品详情
生物活性：
NCT-501 is a potent and selective theophylline-based inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1), inhibits hALDH1A1 with IC50 of 40 nM, typically shows better selectivity over other ALDH isozymes and other dehydrogenases (hALDH1B1, hALDH3A1, and hALDH2, IC50 >57 μM).
体内研究：
NCT-501 (100 μg/animal; i.t.; every alternate day for 20 days) 在 Cal-27 CisR 衍生的异种移植物中表现出 78% 的肿瘤生长抑制。Animal Model:5-6 weeks old male Hsd: Athymic Nude-Foxn1nu (immuno-deficient-mice bearing Cal-27 CisR cells)
Dosage:100μg/animal
Administration:Intra-tumorally (i.t); every alternate day for 20 days
Result:Showed a 78% inhibition in tumor growth in Cal-27 CisR derived xenografts.
体外研究：
NCT-501 在 20 nM 浓度下显示 Cal-27 CisR 细胞系减少 16%，但差异无统计学意义。
NCT-501 is a potent and selective theophylline-based inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1), inhibits hALDH1A1 with IC50 of 40 nM, typically shows better selectivity over other ALDH isozymes and other dehydrogenases (hALDH1B1, hALDH3A1, and hALDH2, IC50 >57 μM).
体内研究：
NCT-501 (100 μg/animal; i.t.; every alternate day for 20 days) 在 Cal-27 CisR 衍生的异种移植物中表现出 78% 的肿瘤生长抑制。Animal Model:5-6 weeks old male Hsd: Athymic Nude-Foxn1nu (immuno-deficient-mice bearing Cal-27 CisR cells)
Dosage:100μg/animal
Administration:Intra-tumorally (i.t); every alternate day for 20 days
Result:Showed a 78% inhibition in tumor growth in Cal-27 CisR derived xenografts.
体外研究：
NCT-501 在 20 nM 浓度下显示 Cal-27 CisR 细胞系减少 16%，但差异无统计学意义。
产品资料
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