产品
编 号：F218131
分子式：C14H12N2O2
分子量：240.26
分子式：C14H12N2O2
分子量：240.26
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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结构图
CAS No: 1800405-30-4
产品详情
生物活性：
KL1333, a derivative of β-lapachone, is an orally available NAD+ modulator. KL1333 reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. KL1333 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. KL1333 protects against Cisplatin-induced ototoxicity in mouse cochlear cultures.
体外研究：
KL1333 是 NAD? 细胞水平的有效调节剂，NAD? 是细胞能量代谢中的中心辅酶。升高的 NAD+ 水平触发 SIRT1 和 AMPK 的激活，随后激活 PGC-1α。
KL1333, a derivative of β-lapachone, is an orally available NAD+ modulator. KL1333 reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. KL1333 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. KL1333 protects against Cisplatin-induced ototoxicity in mouse cochlear cultures.
体外研究：
KL1333 是 NAD? 细胞水平的有效调节剂，NAD? 是细胞能量代谢中的中心辅酶。升高的 NAD+ 水平触发 SIRT1 和 AMPK 的激活，随后激活 PGC-1α。
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