产品
编 号:F002753
分子式:C30H38N4O5
分子量:534.65
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1mg
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5mg
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生物活性:
A12B4C3 is a potent human polynucleotide kinase/phosphatase (hPNKP) inhibitor with an IC50 value of 0.06 μM. A12B4C3 has antiproliferative activity against cancer cells. A12B4C3 can also enhance the radiosensitivity of certain cancer cells.

体外研究:
A12B4C3 (0-10 μM) strongly inhibits hPNKP phosphatase activity.A12B4C3 (0-100 μM; 72 h) reduces A549 and MDA-MB-231 cell proliferation in a dose dependent manner.A12B4C3 (1 μM; 24 h) increases the radiosensitivity of A549 cells.
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