产品
编 号:F217959
分子式:C24H23F4N5O4
分子量:521.46
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10mM*1mL in DMSO
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5mg
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10mg
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25mg
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50mg
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生物活性:
PF-6683324 (Trk-IN-4) is a potent pan-Trk inhibitor in cell-based assays with IC50s of 1.9 nM, 2.6 nM and 1.1 nM for TrkA, TrkB and TrkC, respectively. Anti-hyperalgesic effect.

体外研究:
PF-6683324 (Trk-IN-4) (Compound 10b) exhibits superb Trk selectivity with >95% inhibition of TrkA and >40% inhibition of only 1 other kinase VEGFR2 (cell-based assay for VEGFR2 IC50>5 μM).
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