产品
编 号：F217938
分子式：C10H7Cl2NO4
分子量：276.07
分子式：C10H7Cl2NO4
分子量：276.07
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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50mg
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结构图
CAS No: 1799725-26-0
产品详情
生物活性：
GSK180 is a selective, competitive, and potent inhibitor of kynurenine-3-monooxygenase (KMO), a key enzyme of tryptophan metabolism (IC50, ~6 nM), but shows negligible activity against other enzymes on the tryptophan pathway. GSK180 rapidly changes levels of kynurenine pathway metabolites, and acts as a useful tool to probe the therapeutic potential of KMO inhibition.
体内研究：
GSK180 适用于静脉注射。
体外研究：
GSK180 抑制原代人肝细胞中的内源性 KMO 活性 (IC50=2.6 μM)。GSK180 抑制大鼠 KMO 的效力略低于人类酶 (IC50=7 μM)。
GSK180 is a selective, competitive, and potent inhibitor of kynurenine-3-monooxygenase (KMO), a key enzyme of tryptophan metabolism (IC50, ~6 nM), but shows negligible activity against other enzymes on the tryptophan pathway. GSK180 rapidly changes levels of kynurenine pathway metabolites, and acts as a useful tool to probe the therapeutic potential of KMO inhibition.
体内研究：
GSK180 适用于静脉注射。
体外研究：
GSK180 抑制原代人肝细胞中的内源性 KMO 活性 (IC50=2.6 μM)。GSK180 抑制大鼠 KMO 的效力略低于人类酶 (IC50=7 μM)。
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