产品
编 号：F025180
分子式：C16H13N3O
分子量：263.29
分子式：C16H13N3O
分子量：263.29
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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结构图
CAS No: 1062648-63-8
产品详情
生物活性：
DMT1 blocker 2 is a direct inhibitor of divalent metal transporter 1 (DMT1), with an IC50 of 0.83 μM. DMT1 blocker 2 can block iron uptake by enterocytes in vivo.
体内研究：
DMT1 blocker 2 (50 mg/kg；口服) 在铁吸收过度的急性大鼠模型中阻断肠细胞对铁的摄取。Animal Model:Weanling (3-4 weeks) rats were placed on a low iron diet for four weeks
Dosage:50 mg/kg
Administration:Oral gavage followed 1 h later by an iron challenge
Result:Attenuated the post-challenge serum iron increase.
体外研究：
DMT1 blocker 2 (Compound 12f) (10 μM；24 h) 对 HepG2 细胞没有细胞毒性。 DMT1 blocker 2 (10 μM) 抑制 44% 的 CYP3A4 活性。
DMT1 blocker 2 is a direct inhibitor of divalent metal transporter 1 (DMT1), with an IC50 of 0.83 μM. DMT1 blocker 2 can block iron uptake by enterocytes in vivo.
体内研究：
DMT1 blocker 2 (50 mg/kg；口服) 在铁吸收过度的急性大鼠模型中阻断肠细胞对铁的摄取。Animal Model:Weanling (3-4 weeks) rats were placed on a low iron diet for four weeks
Dosage:50 mg/kg
Administration:Oral gavage followed 1 h later by an iron challenge
Result:Attenuated the post-challenge serum iron increase.
体外研究：
DMT1 blocker 2 (Compound 12f) (10 μM；24 h) 对 HepG2 细胞没有细胞毒性。 DMT1 blocker 2 (10 μM) 抑制 44% 的 CYP3A4 活性。
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