产品
编 号：F215867
分子式：C18H18Cl2N6O
分子量：405.28
分子式：C18H18Cl2N6O
分子量：405.28
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
结构图
CAS No: 179343-17-0
产品详情
生物活性：
PD-089828 is an ATP competitive inhibitor of FGFR-1, PDGFR-β and EGFR (IC50s=0.15, 1.76, and 5.47 μM, respectively) and a noncompetitive inhibitor of c-Src tyrosine kinase (IC50=0.18 μM). PD-089828 also inhibits MAPK with an IC50 of 7.1 μM. PD-089828 inhibits PDGF-, EGF- and bFGF-mediated tyrosine kinase receptor autophosphorylation in vitro. PD-089828 has a long-lasting cellular activity.
体外研究：
PD-089828 (0.5-20 μM; 2 hours) inhibits PDGFR autophosphorylation with an IC50 of 0.82 μM.PD-089828 (1-50 μM; 2 hours) inhibits EGFR autophosphorylation with an IC50 value of 10.9 μM.In A121(p) cells, PD 089828 potently inhibits the phosphorylation of FGFR-1 with an IC50 value of 0.63 μM.PD-089828 (10 μM; 8 days) produces a concentration-related inhibition of serum-stimulated cell growth with an IC50 value of 1.8 μM.PD-089828 inhibits increases in DNA synthesis stimulated by all three growth factors, with IC50 values of 0.8 for PDGF-, 1.7 for EGF- and 0.48 μM for bFGF-induced mitogenesis.
PD-089828 is an ATP competitive inhibitor of FGFR-1, PDGFR-β and EGFR (IC50s=0.15, 1.76, and 5.47 μM, respectively) and a noncompetitive inhibitor of c-Src tyrosine kinase (IC50=0.18 μM). PD-089828 also inhibits MAPK with an IC50 of 7.1 μM. PD-089828 inhibits PDGF-, EGF- and bFGF-mediated tyrosine kinase receptor autophosphorylation in vitro. PD-089828 has a long-lasting cellular activity.
体外研究：
PD-089828 (0.5-20 μM; 2 hours) inhibits PDGFR autophosphorylation with an IC50 of 0.82 μM.PD-089828 (1-50 μM; 2 hours) inhibits EGFR autophosphorylation with an IC50 value of 10.9 μM.In A121(p) cells, PD 089828 potently inhibits the phosphorylation of FGFR-1 with an IC50 value of 0.63 μM.PD-089828 (10 μM; 8 days) produces a concentration-related inhibition of serum-stimulated cell growth with an IC50 value of 1.8 μM.PD-089828 inhibits increases in DNA synthesis stimulated by all three growth factors, with IC50 values of 0.8 for PDGF-, 1.7 for EGF- and 0.48 μM for bFGF-induced mitogenesis.
产品资料
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