产品
编 号：F215655
分子式：C22H35NO3
分子量：361.52
分子式：C22H35NO3
分子量：361.52
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 179113-91-8
产品详情
生物活性：
N-Arachidonylglycine (NA-Gly), a carboxylic analog of the endocannabinoid anandamide (AEA), is a GPR18 agonist (EC50 = 44.5 nM). Unlike AEA, N-Arachidonylglycine has no activity at either CB1 or CB2 receptors. N-Arachidonylglycine inhibits GLYT2 (IC50 = 5.1 μM). N-Arachidonylglycine also is an effective activator of endometrial cell migration.
体内研究：
N-Arachidonylglycine (10 mg/kg; oral) increases blood concentrations of anandamide 9-fold.N-Arachidonylglycine (1.2 mg/kg; oral; once) results in a significant 70% reduction of peritoneal cells.Animal Model:Rats
Dosage:10 mg/kg
Administration:Oral
Result:Inhibition of FAAH, causing a reduction in the hydrolytic cleavage of anandamid.
Animal Model:Mouse (peritonitis model)
Dosage:1.2 mg/kg
Administration:Oral; once
Result:Resulted in a significant 70% reduction of peritoneal cells.
体外研究：
N-Arachidonylglycine (0.1 nM-100 μM; 5 min) drives MAPK activation in GPR18-transfected HEK293 cells.N-Arachidonylglycine shows no activity at GLYT1 or GAT1 at concentrations up to 100 μm.
N-Arachidonylglycine (NA-Gly), a carboxylic analog of the endocannabinoid anandamide (AEA), is a GPR18 agonist (EC50 = 44.5 nM). Unlike AEA, N-Arachidonylglycine has no activity at either CB1 or CB2 receptors. N-Arachidonylglycine inhibits GLYT2 (IC50 = 5.1 μM). N-Arachidonylglycine also is an effective activator of endometrial cell migration.
体内研究：
N-Arachidonylglycine (10 mg/kg; oral) increases blood concentrations of anandamide 9-fold.N-Arachidonylglycine (1.2 mg/kg; oral; once) results in a significant 70% reduction of peritoneal cells.Animal Model:Rats
Dosage:10 mg/kg
Administration:Oral
Result:Inhibition of FAAH, causing a reduction in the hydrolytic cleavage of anandamid.
Animal Model:Mouse (peritonitis model)
Dosage:1.2 mg/kg
Administration:Oral; once
Result:Resulted in a significant 70% reduction of peritoneal cells.
体外研究：
N-Arachidonylglycine (0.1 nM-100 μM; 5 min) drives MAPK activation in GPR18-transfected HEK293 cells.N-Arachidonylglycine shows no activity at GLYT1 or GAT1 at concentrations up to 100 μm.
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