产品
编 号:F215600
分子式:C17H14N2O3
分子量:294.3
产品类型
结构图
CAS No: 179068-02-1
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产品详情
生物活性:
PHCCC is a Group I mGluR antagonist with an IC50 of 3 μM. PHCCC is a selective positive modulator of mGlu4 receptor. Antiparkinsonian effect.
体内研究:
PHCCC (75 nmol/2.5 μl; intracerebroventricular) produces an antiparkinsonian effect in a dopamine depletion akinesia model.
体外研究:
PHCCC potentiated the effect of L-(+)-2-amino-4-phosphonobutyric acid (L-AP4) in inhibiting transmission at the striatopallidal synapse.