产品
编 号:F025107
分子式:C22H16N4O
分子量:352.39
产品类型
结构图
CAS No: 1062368-49-3
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产品详情
生物活性:
ML347 (LDN193719) is a highly selective ALK1/ALK2 inhibitor. ML347 has IC50 values of 46 and 32 nM against ALK1 and ALK2, respectively, >300-fold selective over ALK3. ML347 block the phosphorylation of Smad1/5 by TGF-β1.
体外研究:
ML347 可通过抑制 ALK1/ALK2 来阻断 TGF-β 信号转导。