产品
编 号:F214652
分子式:C16H22O4
分子量:278.34
产品类型
结构图
CAS No: 17851-53-5
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产品详情
生物活性:
Butyl isobutyl phthalate is isolated from the rhizoid of Laminaria japonica. Butyl isobutyl phthalate is a non-competitive α-glucosidase inhibitor with an IC50 value of 38 μM. Butyl isobutyl phthalate shows a hypoglycemic effect and has the potential for diabetes treatment.
体内研究:
Butyl isobutyl phthalate (intragastric administration; 25, 50 or 100 mg/kg; 3 days) results in a more significant reduction in the blood glucose level, with the concentration of blood glucose being 11.50, 8.60 and 6.50 mM, respectively.Animal Model:Streptozocin induced diabetic mice (Male Kunming mice)
Dosage:25, 50 or 100 mg/kg
Administration:Intragastric administration
Result:Had the observed antidiabetes activity in mice.
体外研究:
Butyl isobutyl phthalate exhibits significant, concentration-dependent inhibitory activity against α-glucosidase with an IC50 value of 38 μM.