产品
编 号：F214286
分子式：C20H34O2
分子量：306.48
分子式：C20H34O2
分子量：306.48
产品类型
规格
价格
是否有货
结构图
CAS No: 1783-84-2
产品详情
生物活性：
Dihomo-γ-linolenic acid (DGLA) is a 20-carbon ω-6 fatty acid, with anti-inflammatory and anti-proliferative activities. Dihomo-γ-linolenic acid attenuates atherosclerosis in the apolipoprotein E deficient mouse model system.
体内研究：
Dihomo-γ-linolenic acid (8?mg/mouse; i.g; twice a week; for 35 days) inhibits growth of xenograft tumors in mice bearing human pancreatic cancer cells (BxPC-3) transfected with delta-5-desaturase shRNA.Animal Model:Female nude mice (48 four-week old)
Dosage:8?mg/mouse
Administration:Oral gavage, twice a week, for 35 days
Result:Suppressed metastasis potential in D5D-KD tumors.
体外研究：
Dihomo-γ-linolenic acid attenuates pro-inflammatory gene expression in human and mouse macrophages.Dihomo-γ-linolenic acid (50?μM; 24 hours) attenuates IFN-γ induced phosphorylation of STAT1 on serine 727.Dihomo-γ-linolenic acid attenuates IL-1β and TNF-α induced MCP-1 and ICAM-1 expression in human macrophages.Dihomo-γ-linolenic acid attenuates chemokine-driven monocytic migration and macrophage foam cell formation.Dihomo-γ-linolenic acid attenuates the expression of SR-A and CD36 in human macrophages.Dihomo-γ-linolenic acid modulates mitochondrial respiration.Dihomo-γ-linolenic acid modulates the properties of endothelial cells and VSMC.
Dihomo-γ-linolenic acid (DGLA) is a 20-carbon ω-6 fatty acid, with anti-inflammatory and anti-proliferative activities. Dihomo-γ-linolenic acid attenuates atherosclerosis in the apolipoprotein E deficient mouse model system.
体内研究：
Dihomo-γ-linolenic acid (8?mg/mouse; i.g; twice a week; for 35 days) inhibits growth of xenograft tumors in mice bearing human pancreatic cancer cells (BxPC-3) transfected with delta-5-desaturase shRNA.Animal Model:Female nude mice (48 four-week old)
Dosage:8?mg/mouse
Administration:Oral gavage, twice a week, for 35 days
Result:Suppressed metastasis potential in D5D-KD tumors.
体外研究：
Dihomo-γ-linolenic acid attenuates pro-inflammatory gene expression in human and mouse macrophages.Dihomo-γ-linolenic acid (50?μM; 24 hours) attenuates IFN-γ induced phosphorylation of STAT1 on serine 727.Dihomo-γ-linolenic acid attenuates IL-1β and TNF-α induced MCP-1 and ICAM-1 expression in human macrophages.Dihomo-γ-linolenic acid attenuates chemokine-driven monocytic migration and macrophage foam cell formation.Dihomo-γ-linolenic acid attenuates the expression of SR-A and CD36 in human macrophages.Dihomo-γ-linolenic acid modulates mitochondrial respiration.Dihomo-γ-linolenic acid modulates the properties of endothelial cells and VSMC.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备