产品
编 号:F214171
分子式:C23H22ClFN6O4S2
分子量:565.04
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是否有货
1mg
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5mg
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10mg
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25mg
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生物活性:
ACT-678689 (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM.

体外研究:
TPH comprises two isoforms: TPH2 is mainly expressed in neuronal cell types in the central nervous system (CNS), while TPH1 is mainly expressed in peripheral tissues, including the entrochromaffin cells (EC) in the gut, where it is responsible for synthesizing 5HT that is stored in circulating blood platelets.
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