产品
编 号:F213986
分子式:C31H41N7O9
分子量:655.7
产品类型
结构图
CAS No: 178249-42-8
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产品详情
生物活性:
Nociceptin (1-7) is the N-terminal bioactive fragment of nociceptin (HY-P0183). Nociceptin (1-7) is a potent ORL1?(NOP) receptor agonist with antinociceptive activity. Nociceptin (1-7) combines with nociceptin reduces hyperalgesia in vivo.
体内研究:
Nociceptin (1-7) (intrathecal injection; 150–1200? nmol; single dose) has no significant effect in the nociceptive thermal threshold (hyperalgesia). However, when nociceptin (1–7) is injected simultaneously with nociceptin (3.0?fmol), nociceptin-induced hyperalgesia is significantly reduced.Animal Model:Mice
Dosage:150–1200? nmol
Administration:Intrathecal injection; single dose
Result:Co-treatment with nociceptin could reduce hyperalgesia.