产品
编 号：F213835
分子式：C19H17ClF2N6O
分子量：418.83
分子式：C19H17ClF2N6O
分子量：418.83
产品类型
规格
价格
是否有货
结构图
CAS No: 1781934-50-6
产品详情
生物活性：
AR-C102222 hydrochloride is a potent, competitive, orally active and highly selective inducible nitric oxide synthase (iNOS) inhibitor, with an IC50 of 37 nM. AR-C102222 hydrochloride has antinociception and anti-inflammatory activities.
体内研究：
AR-C102222 (3, 10, 30, 100 mg/kg, P.O.) attenuates arachidonic acid-induced ear inflammation and possesses anti-inflammatory activity.AR-C102222 shows good efficacy in a rat adjuvant-induced arthritis model.Animal Model:Male Balb/c mice (20-25 g).
Dosage:3, 10, 30, 100 mg/kg.
Administration:P.O. 55 min before the administration of 0.6% acetic acid (i.p., 1 mL/100 g volume).
Result:Significantly inhibited arachidonic acid-induced ear inflammation following a dose of 100 mg/kg of has a maximal inhibition of approximately 79%.
AR-C102222 hydrochloride is a potent, competitive, orally active and highly selective inducible nitric oxide synthase (iNOS) inhibitor, with an IC50 of 37 nM. AR-C102222 hydrochloride has antinociception and anti-inflammatory activities.
体内研究：
AR-C102222 (3, 10, 30, 100 mg/kg, P.O.) attenuates arachidonic acid-induced ear inflammation and possesses anti-inflammatory activity.AR-C102222 shows good efficacy in a rat adjuvant-induced arthritis model.Animal Model:Male Balb/c mice (20-25 g).
Dosage:3, 10, 30, 100 mg/kg.
Administration:P.O. 55 min before the administration of 0.6% acetic acid (i.p., 1 mL/100 g volume).
Result:Significantly inhibited arachidonic acid-induced ear inflammation following a dose of 100 mg/kg of has a maximal inhibition of approximately 79%.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备