产品
编 号：F213382
分子式：C22H21Cl2F3N4O2
分子量：501.33
分子式：C22H21Cl2F3N4O2
分子量：501.33
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规格
价格
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结构图
CAS No: 1780372-25-9
产品详情
生物活性：
SB 243213 dihydrochloride is an orally active, selective and high-affinity 5-HT2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 dihydrochloride shows greater than a 100-fold selectivity over a wide range of neurotransmitter receptors, enzymes and ion channels. SB 243213 dihydrochloride has improved anxiolytic profile and has the potential for schizophrenia and motor disorders.
体内研究：
SB 243213 dihydrochloride (0.1-10 mg/kg; p.o.; 1 h pre-test) dose-dependently and significantly increases the amount of time rats spent in social interaction over 15 min under brightly lit conditions and in an unfamiliar test box. SB 243213 dihydrochloride (0.3 mg/kg; p.o.; 1 h pre-test) significantly increases time spent in social interaction. Animal Model:Male Sprague-Dawley experimentally naive rats (220-300 g)
Dosage:0.1, 0.3, 1, 3, 10 mg/kg
Administration:p.o.; 1 hour pre-test
Result:Dose-dependently and significantly increased the amount of time rats spent in social interaction over 15 min under brightly lit conditions and in an unfamiliar test box.
体外研究：
SB 243213 dihydrochloride shows little affinity (pKiSB 243213 dihydrochloride 相关抗体:
SB 243213 dihydrochloride is an orally active, selective and high-affinity 5-HT2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 dihydrochloride shows greater than a 100-fold selectivity over a wide range of neurotransmitter receptors, enzymes and ion channels. SB 243213 dihydrochloride has improved anxiolytic profile and has the potential for schizophrenia and motor disorders.
体内研究：
SB 243213 dihydrochloride (0.1-10 mg/kg; p.o.; 1 h pre-test) dose-dependently and significantly increases the amount of time rats spent in social interaction over 15 min under brightly lit conditions and in an unfamiliar test box. SB 243213 dihydrochloride (0.3 mg/kg; p.o.; 1 h pre-test) significantly increases time spent in social interaction. Animal Model:Male Sprague-Dawley experimentally naive rats (220-300 g)
Dosage:0.1, 0.3, 1, 3, 10 mg/kg
Administration:p.o.; 1 hour pre-test
Result:Dose-dependently and significantly increased the amount of time rats spent in social interaction over 15 min under brightly lit conditions and in an unfamiliar test box.
体外研究：
SB 243213 dihydrochloride shows little affinity (pKiSB 243213 dihydrochloride 相关抗体:
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