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编 号:F213213
分子式:C15H10ClFN2
分子量:272.7
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生物活性:
MFZ 10-7 hydrochloride is a highly potent and selective mGluR5 NAM (negative allosteric modulator), with a Ki of 0.67 nM for rat mGluR5. MFZ 10-7 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

体内研究:
MFZ 10-7 hydrochloride 可降低口服蔗糖自我-给药速率但对总蔗糖摄入量没有影响。

体外研究:
与 mGluR5 相比,MFZ 10-7 hydrochloride 对 MAO-B (单胺氧化酶-B 酶)和 TXA2 (血栓烷 A2 受体)的亲和力分别低约 1150 倍和 3000 倍。
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