产品
编 号：F213212
分子式：C22H28ClNO5
分子量：421.91
分子式：C22H28ClNO5
分子量：421.91
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 1779796-27-8
产品详情
生物活性：
LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a.
体内研究：
LY2365109 hydrochloride (0.3-30 mg/kg; p.o.) produces dose-dependent elevations in CSF levels of glycine.LY2365109 hydrochloride increases seizure thresholds in mice.Animal Model:Male Sprague-Dawley rats (250-300 g)
Dosage:0.3 mg/kg, 1 mg/kg, 5 mg/kg, 10 mg/kg, 30 mg/kg
Administration:Oral administration
Result:Produced dose-dependent elevations in CSF levels of glycine measured 1 h after dosing.
LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a.
体内研究：
LY2365109 hydrochloride (0.3-30 mg/kg; p.o.) produces dose-dependent elevations in CSF levels of glycine.LY2365109 hydrochloride increases seizure thresholds in mice.Animal Model:Male Sprague-Dawley rats (250-300 g)
Dosage:0.3 mg/kg, 1 mg/kg, 5 mg/kg, 10 mg/kg, 30 mg/kg
Administration:Oral administration
Result:Produced dose-dependent elevations in CSF levels of glycine measured 1 h after dosing.
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