产品
编 号：F211845
分子式：C34H40Cl2N4O6
分子量：671.61
分子式：C34H40Cl2N4O6
分子量：671.61
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规格
价格
是否有货
100mg
询价
询价
结构图
CAS No: 17696-69-4
产品详情
生物活性：
Hematoporphyrin dihydrochloride (Hematoporphyrin IX dihydrochloride), a photosensitizer, is a substrate for affinity chromatography of heme-binding proteins. Hematoporphyrin dihydrochloride can induce apoptosis in U87 glioma cells and decrease tumor growth in vivo when exposed to red light.
体内研究：
Hematoporphyrin（5-10 mg/kg；腹膜内注射 2 个月）在红光照射下可迅速减小大鼠的肿瘤大小，这是由于光活化卟啉对肿瘤细胞的直接作用和对血管的二次作用引起的坏死。Animal Model:Wistar albino rats of both sexes (20 d; 60-80 g) bearing a subcutaneous solid Yoshida hepatoma AH-130
Dosage:5, 10 mg/kg
Administration:I.p. daily during the initial 10 days and biweekly for the next 2 months
Result:No tumor could be palpated a few days after exposure of the rats to light.The skin healed completely and regrowth of the hair occurred.Massive coagulation necrosis of the tumor 24 h after phototreatment (×40).
体外研究：
Hematoporphyrin dihydrochloride (20-120 nM；60 分钟) 剂量依赖性地抑制 U87 和 U251 胶质瘤细胞的细胞活力，IC50 分别为 85 和 166 nM。 Hematoporphyrin (85 nM；60 min) 通过诱导 U87 细胞中的 ROS 诱导细胞凋亡。 Hematoporphyrin (85 nM；60 min) 诱导细胞形态学变化红光下 U87 细胞的收缩、碎裂。
Hematoporphyrin dihydrochloride (Hematoporphyrin IX dihydrochloride), a photosensitizer, is a substrate for affinity chromatography of heme-binding proteins. Hematoporphyrin dihydrochloride can induce apoptosis in U87 glioma cells and decrease tumor growth in vivo when exposed to red light.
体内研究：
Hematoporphyrin（5-10 mg/kg；腹膜内注射 2 个月）在红光照射下可迅速减小大鼠的肿瘤大小，这是由于光活化卟啉对肿瘤细胞的直接作用和对血管的二次作用引起的坏死。Animal Model:Wistar albino rats of both sexes (20 d; 60-80 g) bearing a subcutaneous solid Yoshida hepatoma AH-130
Dosage:5, 10 mg/kg
Administration:I.p. daily during the initial 10 days and biweekly for the next 2 months
Result:No tumor could be palpated a few days after exposure of the rats to light.The skin healed completely and regrowth of the hair occurred.Massive coagulation necrosis of the tumor 24 h after phototreatment (×40).
体外研究：
Hematoporphyrin dihydrochloride (20-120 nM；60 分钟) 剂量依赖性地抑制 U87 和 U251 胶质瘤细胞的细胞活力，IC50 分别为 85 和 166 nM。 Hematoporphyrin (85 nM；60 min) 通过诱导 U87 细胞中的 ROS 诱导细胞凋亡。 Hematoporphyrin (85 nM；60 min) 诱导细胞形态学变化红光下 U87 细胞的收缩、碎裂。
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