产品
编 号：F211810
分子式：C25H29N3O2
分子量：403.52
分子式：C25H29N3O2
分子量：403.52
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
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10mg
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50mg
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100mg
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结构图
CAS No: 17692-51-2
产品详情
生物活性：
Metergoline is a serotonin (5-HT) receptor and dopamine receptors antagonist, with pKis of 8.64, 8.75 and 8.75 for 5-HT2A, 5-HT2B and 5-HT2C, respectively. Metergoline is a high-affinity ligand for the h5-HT7 receptor, with a Ki of 16 nM. Metergoline is also a reversible neural Na+ channels inhibitor. Metergoline is commonly used for the research of seasonal affective disorder, prolactin hormone regulation.
体内研究：
Metergoline (5 mg/kg；ip) 完全阻断对鞘内注射 5-HT (2 μg) 的反应。Animal Model:Male albino mice (25-40 g)
Dosage:5 mg/kg
Administration:Intraperitoneal injection
Result:Inhibited bites or scratches induced by 5-HT (2 μg).
体外研究：
Metergoline (3 μM) 引起 Na+ 电流稳态激活曲线的 6.8±1.2 mV 去极化偏移，并且不改变失活曲线。
Metergoline is a serotonin (5-HT) receptor and dopamine receptors antagonist, with pKis of 8.64, 8.75 and 8.75 for 5-HT2A, 5-HT2B and 5-HT2C, respectively. Metergoline is a high-affinity ligand for the h5-HT7 receptor, with a Ki of 16 nM. Metergoline is also a reversible neural Na+ channels inhibitor. Metergoline is commonly used for the research of seasonal affective disorder, prolactin hormone regulation.
体内研究：
Metergoline (5 mg/kg；ip) 完全阻断对鞘内注射 5-HT (2 μg) 的反应。Animal Model:Male albino mice (25-40 g)
Dosage:5 mg/kg
Administration:Intraperitoneal injection
Result:Inhibited bites or scratches induced by 5-HT (2 μg).
体外研究：
Metergoline (3 μM) 引起 Na+ 电流稳态激活曲线的 6.8±1.2 mV 去极化偏移，并且不改变失活曲线。
产品资料
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