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编 号：F211570
分子式：C14H16N4O3S
分子量：320.37
分子式：C14H16N4O3S
分子量：320.37
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CAS No: 176644-21-6
产品详情
生物活性：
Eniporide (EMD 96785) is a Na(+)/H(+) exchange (NHE) inhibitor. Eniporide specifically inhibits the NHE-1 isoform. Eniporide improves cardiac performance inhibition associated with myocardial ischemia/reperfusion in animals, and limits infarct size in experimental models. Eniporide regulates cardiac performance and high-energy phosphate content in clinically relevant pig models of CPB and cardiac arrest.
体内研究：
Eniporide (3mg /kg；静脉注射；心脏骤停前全身输注) 可改善晶体性心脏骤停引起的缺血/再灌注健康猪心脏的功能和高能量磷酸盐含量。Animal Model:Clinically relevant pig models of cardiopulmonary bypass (CPB) and cardioplegia
Dosage:3 mg/kg
Administration:IV; systemic infusion before cardioplegia with added 2 μM Eniporide or not
Result:Had no effect on standard hemodynamics including vascular pressures and cardiac index nor for cardiac performance factors.Reduced myocardial edema and improves heart function.
体外研究：
ENIPORIDE 是一种有效的 Na+/H+ 交换抑制剂。
Eniporide (EMD 96785) is a Na(+)/H(+) exchange (NHE) inhibitor. Eniporide specifically inhibits the NHE-1 isoform. Eniporide improves cardiac performance inhibition associated with myocardial ischemia/reperfusion in animals, and limits infarct size in experimental models. Eniporide regulates cardiac performance and high-energy phosphate content in clinically relevant pig models of CPB and cardiac arrest.
体内研究：
Eniporide (3mg /kg；静脉注射；心脏骤停前全身输注) 可改善晶体性心脏骤停引起的缺血/再灌注健康猪心脏的功能和高能量磷酸盐含量。Animal Model:Clinically relevant pig models of cardiopulmonary bypass (CPB) and cardioplegia
Dosage:3 mg/kg
Administration:IV; systemic infusion before cardioplegia with added 2 μM Eniporide or not
Result:Had no effect on standard hemodynamics including vascular pressures and cardiac index nor for cardiac performance factors.Reduced myocardial edema and improves heart function.
体外研究：
ENIPORIDE 是一种有效的 Na+/H+ 交换抑制剂。
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