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编 号：F024928
分子式：C28H45NO5S
分子量：507.73
分子式：C28H45NO5S
分子量：507.73
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CAS No: 1061337-51-6
产品详情
生物活性：
Lefamulin (BC-3781) is an orally active antibiotic. Lefamulin inhibits protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome. Lefamulin has anti-inflammatory activity. Lefamulin can be used in the research of bacterial infections, such as bacterial pneumonia.
体内研究：
Lefamulin (10-140 mg/kg, s.c.) shows anti-inflammatory effect on LPS-induced lung neutrophilia mouse model.Lefamulin (1.25-160 mg/kg, s.c.) shows antibacterial effect in S. pneumoniae or S. aureus challenged lung infection mice.Animal Model:LPS-induced lung neutrophilia mouse model
Dosage:10-140 mg/kg
Administration:Subcutaneous injection (s.c.)
Result:Reduced BALF neutrophil cell counts.Reduced pro-inflammatory cytokine (TNF-α, IL-6, IL-1β, and GM-CSF), chemokine (CXCL-1, CXCL-2, and CCL-2) and MMP-9 levels in mouse lung tissue.
体外研究：
Lefamulin (0-1 mg/L) shows inhibitory activity against C. trachomatis, N. gonorrhoeae, and M. genitalium.Lefamulin shows potent activity against all M. pneumoniae strains with MIC values of ≤0.008 μg/mL.
Lefamulin (BC-3781) is an orally active antibiotic. Lefamulin inhibits protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome. Lefamulin has anti-inflammatory activity. Lefamulin can be used in the research of bacterial infections, such as bacterial pneumonia.
体内研究：
Lefamulin (10-140 mg/kg, s.c.) shows anti-inflammatory effect on LPS-induced lung neutrophilia mouse model.Lefamulin (1.25-160 mg/kg, s.c.) shows antibacterial effect in S. pneumoniae or S. aureus challenged lung infection mice.Animal Model:LPS-induced lung neutrophilia mouse model
Dosage:10-140 mg/kg
Administration:Subcutaneous injection (s.c.)
Result:Reduced BALF neutrophil cell counts.Reduced pro-inflammatory cytokine (TNF-α, IL-6, IL-1β, and GM-CSF), chemokine (CXCL-1, CXCL-2, and CCL-2) and MMP-9 levels in mouse lung tissue.
体外研究：
Lefamulin (0-1 mg/L) shows inhibitory activity against C. trachomatis, N. gonorrhoeae, and M. genitalium.Lefamulin shows potent activity against all M. pneumoniae strains with MIC values of ≤0.008 μg/mL.
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